Angiotensin-Converting Enzyme Polymorphism affects Outcome of local Chinese with Acute Lung Injury
陆晓旻1 陈光健1 杨毅1 邱海波1
东南大学附属中大医院重症医学科
Introduction: Relationship between ACE insertion/deletion (I/D) polymorphism and the prognosis of local Chinese patients with ALI was investigated; meanwhile, the mechanisms involved were explored.
Methods: ACE I/D polymorphism was detected and then clinical data of ALI patients were compared. Also, peripheral blood mononuclear cells (PBMC) were isolated from healthy volunteers with different ACE genotypes. LPS-induced ACE gene mRNA expression and ACE activity was measured.
Results: There was no significant difference in ACE I/D polymorphism among all groups. APACHEⅡ score was higher in DD-genotype subgroup. The 28-day mortality was significantly different (17.4, 26.8 and 64.3% for II, ID, and DD, respectively; P = 0.013). Furthermore, LPS-induced ACE mRNA expression and ACE activity from PBMC in DD-genotype subgroup were both significantly higher than those in the other two subgroups.
Conclusions: ACEI/D polymorphism is a prognostic factor for ALI.
Methods: ACE I/D polymorphism was detected and then clinical data of ALI patients were compared. Also, peripheral blood mononuclear cells (PBMC) were isolated from healthy volunteers with different ACE genotypes. LPS-induced ACE gene mRNA expression and ACE activity was measured.
Results: There was no significant difference in ACE I/D polymorphism among all groups. APACHEⅡ score was higher in DD-genotype subgroup. The 28-day mortality was significantly different (17.4, 26.8 and 64.3% for II, ID, and DD, respectively; P = 0.013). Furthermore, LPS-induced ACE mRNA expression and ACE activity from PBMC in DD-genotype subgroup were both significantly higher than those in the other two subgroups.
Conclusions: ACEI/D polymorphism is a prognostic factor for ALI.
