Early Elevated HMGB1 Level Predicting the Outcome in Exertional Heatstroke
童华生1
广州军区广州总医院
Conclusions HMGB1 level on admission is an indicator of the severity of illness and an useful mortality predictor in exertional heatstroke.
Early Elevated HMGB1 Level Predicting the Outcome in Exertional Heatstroke
童华生1
广州军区广州总医院
Methods Plasma HMGB1 was detected by the enzyme-linked immunosorbent assay method.C-reactive protein (CRP) was measured using a fully automated IMMAGE Immunochemistry System. HMGB1 in the culture supernatant of patient peripheral blood monocyte was measured by immunoblotting.
Results HMGB1 released peak levels occurring within 6-13hrs postheatstroke. HMGB1 levels elevated above levels in healthy volunteers through the follwing 6 days postheatstroke (P<0.005). Positive correlation (r = 0.798, P <0.001) was found between APACHE Ⅱ scores and HMGB1 levels on admission.HMGB1 levels on admission between survivors and nonsurvivors were different significantly (P<0.001). Receiver operating curve analysis showed that at a level of 47ng/mL,HMGB1 levels on admission indicated lethality, with 77.4% sensitivity and 84.2% specificity.
Conclusions HMGB1 level on admission is an indicator of the severity of illness and an useful mortality predictor in exertional heatstroke.
