THE STUDY OF CHLORHEXIDINE DIACETATE IN BACTERIAL COLONIZATION IN RESPIRATORY TRACT
谭若铭1 瞿洪平1
上海交通大学医学院附属瑞金医院呼吸ICU
ObjectiveThis study is to investigate the impact of decolonization with 0.05% chlorhexidine diacetate on the rate of bacterial colonization in respiratory tract.
Methods180 patients admitted to RICU between 2007 and 2009 were randomized to receive oral cleansing twice daily with either 0.05% chlorhexidine diacetate (CHX) or normal saline (NS). Samples of sputum were collected from all recruited patients on admission and every 7 days after or when clinical respiratory infections were suspected. The rates of bacterial colonization in respiratory tract were analyzed.
ResultsA total of 263 clinically isolated strains were collected. Colonization rates of respiratory tracts were reduced by 37% (p<0.001) in CHX. Colonization rates of MRSA and P. aeruginosa were reduced by 61% (p<0.05) and 59% (p<0.05) in CHX group, respectively.
ConclusionOrophayngeal decolonization by oral cleansing with chlorhexidine could reduce the colonization rates in respiratory tracts in ICU patients.
Methods180 patients admitted to RICU between 2007 and 2009 were randomized to receive oral cleansing twice daily with either 0.05% chlorhexidine diacetate (CHX) or normal saline (NS). Samples of sputum were collected from all recruited patients on admission and every 7 days after or when clinical respiratory infections were suspected. The rates of bacterial colonization in respiratory tract were analyzed.
ResultsA total of 263 clinically isolated strains were collected. Colonization rates of respiratory tracts were reduced by 37% (p<0.001) in CHX. Colonization rates of MRSA and P. aeruginosa were reduced by 61% (p<0.05) and 59% (p<0.05) in CHX group, respectively.
ConclusionOrophayngeal decolonization by oral cleansing with chlorhexidine could reduce the colonization rates in respiratory tracts in ICU patients.
