重症急性胰腺炎合并腹高压新模型

柯路¹ 李维勤¹ 倪海滨¹ 童智慧¹
南京军区南京总医院

目的 he aim of this study was to assess the effect of intra-abdominal hypertension combined with severe acute pancreatitis(SAP) on hemodynamics, systemic oxygenation, and organ damage in  porcine . 
方法 e used a N₂ pneumoperitoneum to increase the IAP to 30 mmHg in 6 of 12 SAP animals thereafter and keep constant during the experiment. Control animals (n=6) only received sham operation without inflation of N₂. The investigation period was 12 h.
结果 In the study group, cardiac output decreased more significantly compared to SAP animals. Furthermore, AST, creatinine, SUN and lactate increased significantly in the study group paralleled with profoundly decrease in S_vO_2. The histopathological analysis also revealed higher grade injury of liver, intestine and lung in the study group.
结论 ere were remarkable and relatively irreversible effects on global hemodynamics and organ function in response to sustained IAH of 12h with the underlying condition of SAP.