髙渗盐水复苏在重症急性胰腺炎猪模型的应用

倪海滨¹ 李维勤¹ 柯路¹ 童智慧¹
南京军区南京总医院

目的 he study was to assess the effect of of hypertonic saline resuscitation on hemodynamics, systemic oxygenation, and organ damage in a 12h lasting porcine model of severe acute pancreatitis(SAP).
方法 ighteen anesthetized and mechanically ventilated pigs were divided into three groups: HTS group; LR group, and sham-operated control group. Hemodynamic parameters ，urine output, oxygenation parameters，as well as serum parameters were recorded
结果 n the study group, cardiac output decreased less significantly compared to LR group，Furthermore, AST, creatinine, and lactate increased significantly in all SAP animals but the tendency was slower in the HTS group.
结论 n early administration with hypertonic saline generally improves haemodynamics and oxygenation of peripheral tissues characterized by the preservation of cardiac output and lower lactate level.