Effects of Edaravone on Superoxide Dismutase of the Hippocampus of Sepsis Rats

许涛¹
武汉普爱医院

 

Objective  To research the effects and potential mechanism of free radical scavenger on rats with sepsis. Methods  Model rats with sepsis were constructed and randomly divided into 2 groups. Free radical scavenger edaravone were used on rats in group A for 5 days while not used in group B. 20 normal SD rats as control were group C. Super oxide dismutase (SOD) were detected from the serum. Reverse transcription PCR and western blot assays were used to detect the expression level of forkhead box O1 (FOXO1) in hippocampal tissues. Results  The levels of SOD in sepsis rats (group A and group B) were much lower than those in group C, and raised after free radical scavenger was used （P＜0.05）. The expression of FOXO1 in sepsis rats were raised while attenuated after using free radical scavenger（P＜0.05）. Conclusion Free radical scavenger can increase the expression of SOD and enhance to clear free radicals. The possible role maybe correlated to FOXO pathway.