摘要 目的：探讨腺苷蛋氨酸在治疗心脏术后急性肝功能损害的疗效。方法：将400例心脏术后肝功能损害的患者随机分为两组，治疗组和对照组各200例。对照组用综合治疗(不加用任何退黄的药物)，治疗组在综合治疗的基础上加用腺苷蛋氨酸1 000 mg，溶于5%葡萄糖溶液50mL中静脉泵入，每日1次。结果：治疗组肝功能损害恢复情况优于对照组，两组差异有显著性（P<0.05）。结论：腺苷蛋氨酸在治疗心脏术后肝功能损害上对促进肝脏代谢、修复损伤的肝细胞和改善肝功能有明显疗效。腺苷蛋氨酸是目前临床治疗心脏术后肝功能损害方面比较理想安全的药物。

Abstract Objective：To investigate the therapeutic effect of ademetionine in patients with acute liver damage after cardiac operation. Methods：400 patients with acute liver damage after cardiac operation were randomly divided into tow groups:the control group(200 patients) received combined therapy(without any anti-choloplania drugs)，and the therapy group(200 patients)received combined therapy plus ademetionine 1000 mg in 5%glucose solution 50 ml iv by pump qd. Results：The recovery of liver function in the therapy group was superior to that in the control group(P<0.05).There were significantly differences between the two groups (P<0.05).Conclusion：Ademetionine can promote liver metabolism，repair the injury of hepatic cell and improve liver function obviously.It is the effective and safe drug in the treatment of patients with acute liver damage after cardiac operation.